Cancer from A to Z

Types of cancer, how to prevent them, diagnosis and treatment.


Cancer of Unknown Primary (CUP)

Tumors are defined as cancer of unknown primary (CUP) when cancer cells are found in the body, but the site where they originated cannot be determined. Studies have shown that CUP is often found in the lungs or pancreas. Some other common CUP sites include the colon, rectum, breast, bile ducts, stomach and kidney. CUP is responsible for up to 5% of all diagnosed cancers, although the percentage varies because of the extent of evaluation.


At this moment there are no events of Cancer of Unknown Primary (CUP)


At the moment there are no courses of Cancer of Unknown Primary (CUP)

Clinical trials
Ensayo de fase 1a/2a, abierto y multicéntrico, para investigar la seguridad, tolerabilidad y actividad antitumoral de dosis repetidas de Sym015, una mezcla de anticuerpos monoclonales dirigida frente al receptor MET, en pacientes con tumores malignos sólidos en fase avanzada
Estudio fase IIIB, prospectivo, randomizado, abierto que evalúa la eficacia y seguridad de Heparina/Edoxaban versus Dalteparina en tromboembolismo venoso asociado con cáncer.
Tumores sólidos. Antiemesis Estudio fase III, multicéntrico, aleatorizado, doble ciego, con control activo para evaluar la seguridad y eficacia de Rolapitant en la prevención de náuseas y vómitos por la quimioterapia (NVIQ) en pacientes que reciben quimioterapia altamente emética (QAE). A phase III, multicenter, randomized, double blind, placebo controlled study of the safety and efficacy of Rolapitant for the treatment of Chemotherapy-induced nausea and vomiting in subjects receiving highly Emetogenic Chemotherapy (HEC)
Ensayo clínico en fase I de determinación de dosis del antiangiogénico multidiana Dovitinib (TKI258) más paclitaxel en pacientes con tumores sólidos.

Diagnosing cancer of unknown primary (CUP) starts with a full patient history, physical examination and blood tests, as well as X-ray, CT scan and other radiologic studies as needed. Usually a biopsy is done early and reviewed thoroughly under a microscope and a pathology report is created.

A patient’s personal history (e.g., heavy smoking), family history of cancer, pattern of presentation (whether the cancer was seen in the lungs or bones or liver) and pathology can help a doctor narrow down the possible primary sites. Some specialists are even using state-of-the-art genetic and proteomic testing to derive a “signature” from cancer cells that can identify their origins.

Patients with cancer of unknown primary (CUP) are treated without knowing the cancer type. The treatment of CUP depends on several factors:

  • Extent: the number of areas of the body affected by CUP tumor and the size of these cancerous areas
  • Site: what organs are affected - lymph nodes, liver, lungs, bones, etc.
  • Performance status: determining if the patient will be able to tolerate treatment

Surgery may be used for patients whose cancer is in only one area, depending on the site. For some patients, surgery may be combined with chemotherapy or radiation therapy.

Chemotherapy is usually used on patients with metastases in many areas of the body.

Clinical trials may offer new, innovative treatments for CUP.